Classification of networks-on-chip in the context of analysis of promising self-organizing routing algorithms

This paper contains a detailed analysis of the current state of the network-on-chip (NoC) research field, based on which the authors propose the new NoC classification that is more complete in comparison with previous ones. The state of the domain associated with wireless NoC is investigated, as the transition to these NoCs reduces latency. There is an assumption that routing algorithms from classical network theory may demonstrate high performance. So, in this article, the possibility of the usage of self-organizing algorithms in a wireless NoC is also provided. This approach has a lot of advantages described in the paper. The results of the research can be useful for developers and NoC manufacturers as specific recommendations, algorithms, programs, and models for the organization of the production and technological process.Comment: 10 p., 5 fig. Oral presentation on APSSE 2021 conferenc

Targeted Inhibition of CD133+ Cells in Oral Cancer Cell Lines

Resistance to treatment and the appearance of secondary tumors in head and neck squamous cell carcinomas (HNSCC) have been attributed to the presence of cells with stem-cell-like properties in the basal layer of the epithelium at the site of the lesion. In this study, we tested the hypothesis that these putative cancer stem cells (CSC) in HNSCC could be specifically targeted and inhibited. We found that 9 of 10 head and neck tumor biopsies contained a subpopulation of cells that expressed CD133, an unusual surface-exposed membrane-spanning glycoprotein associated with CSC. A genetically modified cytolethal distending toxin (Cdt), from the periodontal pathogen Aggregatibacter actinomycetemcomitans , was conjugated to an anti-human CD133 monoclonal antibody (MAb). The Cdt-MAb complex preferentially inhibited the proliferation of CD133+ cells in cultures of established cell lines derived from HNSCC. Inhibition of the CD133+ cells was rate- and dose-dependent. Saturation kinetics indicated that the response to the Cdt-MAb complex was specific. Healthy primary gingival epithelial cells that are native targets of the wild-type Cdt were not affected. Analysis of these data provides a foundation for the future development of new therapies to target CSC in the early treatment of HNSCC. Abbreviations: Cdt, cytolethal distending toxin; CSC, cancer stem cells; HNSCC, head and neck squamous cell carcinoma; MAb, monoclonal antibody. © 2011 International & American Associations for Dental Research

From colloidal CdSe quantum dots to microscale optically anisotropic supercrystals through bottom-up self-assembly

This is the author accepted manuscript. The final version is available on open access from Royal Society of Chemistry via the DOI in this recordThe development of fabrication techniques for novel nanostructured materials is one of the key tasks of modern materials science. One pathway to successfully complete this task is the bottom-up assembly of colloidal nanoparticles into ordered superstructures, possessing both the properties of individual nanoparticles and further novel properties resulting from their interactions. However, nanoparticle self-assembly depends on a variety of parameters, which makes the precise control of this process a complicated problem. Here, the time course of quantum dot (QD) self-assembly into ordered superstructures has been analyzed, along with the evolution of their morphological and optical properties. QD self-assembly occurs through two distinct stages (homo- and hetero-geneous), leading to the formation of supercrystals with a layered morphology. Analysis of the optical properties throughout the superstructures’ growth has shown that the absorption and photoluminescence (PL) bands are blue shifted, retaining almost the same PL lifetimes as in the initial QD solution. The supercrystals formed possess a further unique optical property caused by their layered morphology; namely, a four-fold symmetry characterized by strong birefringence. Such supercrystals may be used for the fabrication of microscale optical paths with high extinction coefficients and specific polarization properties for novel optoelectronic devices.This study was supported by the Ministry of Education and Science of the Russian Federation through the grant No. 14.584.21.0032 (ID RFMEFI58417X0032), the Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom via the EPSRC Centre for Doctoral Training in Electromagnetic Metamaterials (Grant No. EP/L015331/1) and via EP/N035569/1, and the Royal Society via International Exchange Grant No. 2016/R1

The level of neurotrophic factor of the brain during hypoxic-ischemic encephalopathy in infants

In work changes of level of serumal biomarkers at children are defined. The established changes can explain to some extent disturbances of adaptic and recovery processes in nervous tissue in response to its hypoxemic damage.В работе определены изменения уровня сывороточных биомаркеров у детей. Установленные изменения могут в определенной степени объяснить нарушения адаптационных и восстановительных процессов в нервной ткани в ответ на ее гипоксическое повреждение

Micromechanical Properties of Injection-Molded Starch–Wood Particle Composites

The micromechanical properties of injection molded starch–wood particle composites were investigated as a function of particle content and humidity conditions. The composite materials were characterized by scanning electron microscopy and X-ray diffraction methods. The microhardness of the composites was shown to increase notably with the concentration of the wood particles. In addition,creep behavior under the indenter and temperature dependence were evaluated in terms of the independent contribution of the starch matrix and the wood microparticles to the hardness value. The influence of drying time on the density and weight uptake of the injection-molded composites was highlighted. The results revealed the role of the mechanism of water evaporation, showing that the dependence of water uptake and temperature was greater for the starch–wood composites than for the pure starch sample. Experiments performed during the drying process at 70°C indicated that the wood in the starch composites did not prevent water loss from the samples.Peer reviewe

Health-saving technologies as a means of inclusion enhancement in preschool institutions.

The purpose of the present article is to show the experience of inclusion enhancement in the kindergarten "Romashka" located in the town of Sovietsky, the Khanty-Mansiysk autonomous district. Health-saving technologies aimed at preserving preschoolers' physical health have been used as a means of inclusion enhancement. (C) 2016 The Authors. Published by Elsevier Ltd

Health-saving technologies as a means of inclusion enhancement in preschool institutions.

The purpose of the present article is to show the experience of inclusion enhancement in the kindergarten "Romashka" located in the town of Sovietsky, the Khanty-Mansiysk autonomous district. Health-saving technologies aimed at preserving preschoolers' physical health have been used as a means of inclusion enhancement. (C) 2016 The Authors. Published by Elsevier Ltd